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Article Publish Status: FREE
Abstract Title:

Biochanin A Inhibits Glioblastoma GrowthRestricting Glycolysis and Mitochondrial Oxidative Phosphorylation.

Abstract Source:

Front Oncol. 2021 ;11:652008. Epub 2021 Jul 8. PMID: 34307130

Abstract Author(s):

Qiang Dong, Qiao Li, Lei Duan, Hang Yin, Xiaoqing Wang, Yang Liu, Bo Wang, Kun Li, Xuan Yao, Guoqiang Yuan, Yawen Pan

Article Affiliation:

Qiang Dong

Abstract:

Abnormal metabolism serves a critical role in glioblastoma (GBM). Biochanin A (BCA), a flavonoid phenolic compound found in edible and herbal plants, has antioxidative and antitumor activities. However, it remains unclear whether BCA has an effect on energy metabolism. The aim of the present study was to evaluate the anticancer effects and molecular mechanism of the effect of BCA on energy metabolism. We observed that BCA inhibited the growth of U251 cells by the mitochondria-mediated intrinsic apoptotic pathway. BCA treatment reduced metabolic function, repressed mitochondrial membrane potential, and increased the production of reactive oxygen species (ROS) in GBM. In addition, we found that BCA decreased aerobic glycolysis by inactivation of the AKT/mTOR pathway. Taken together, the results demonstrate that treatment with BCA inhibited the proliferation of GBM by regulating metabolic reprogramming.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032)

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