Bisphenol S binds into a binding pocket of K-Ras4B. - GreenMedInfo Summary
The Bisphenol A analogue Bisphenol S binds to K-Ras4B - implications for 'BPA-free' plastics.
FEBS Lett. 2016 Feb ;590(3):369-75. Epub 2016 Feb 3. PMID: 26867649
K-Ras4B is a small GTPase that belongs to the Ras superfamily of guanine nucleotide-binding proteins. GTPases function as molecular switches in cells and are key players in intracellular signalling. Ras has been identified as an oncogene and is mutated in more than 20% of human cancers. Here, we report that Bisphenol S binds into a binding pocket of K-Ras4B previously identified for various low molecular weight compounds. Our results advocate for more comprehensive safety studies on the toxicity of Bisphenol S, as it is frequently used for Bisphenol A-free food containers.