Bisphenol S Interacts with Catalase and Induces Oxidative Stress in Mouse Liver and Renal Cells.
J Agric Food Chem. 2016 Aug 10. Epub 2016 Aug 10. PMID: 27508457
Bisphenol S (BPS) is present in multitudinous consumer products and detected in both the food and water. It also has been a main substitute for BPA in food packaging industry. Yet, toxicity of BPS is not fully understood. The present study of the toxicity of BPS was divided into two parts. Firstly, oxidative stress, cell viability, apoptosis level and catalase (CAT) activity in mouse hepatocytes and renal cells were investigated after BPS exposure. After 12 h incubation with BPS, all of these parameters of hepatocytes and renal cells changed more than 15% as the concentration of BPS ranged from 0.1 mM to 1 mM. Secondly, the direct interaction between BPS and CAT on the molecule level was investigated by multiple spectra methods and molecular docking investigations. BPS changed the structure and the activity of CAT through binding to Gly 117 residue on the substrate channel of the enzyme. The main binding forces were hydrogen bond and hydrophobic force.