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Abstract Title:

Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats:andstudies.

Abstract Source:

J Biomol Struct Dyn. 2021 Feb ;39(3):1017-1028. Epub 2020 Feb 13. PMID: 32028848

Abstract Author(s):

Hady Keita, Cleydson Breno Rodrigues Dos Santos, Matheus Mercês Ramos, Elias Carvalho Padilha, Rodolfo Bortolozo Serafim, Andres Navarrete Castro, Jesus Rafael Rodriguez Amado, Gabriel Monteiro da Silva, Irlon Maciel Ferreira, Silvana Giuliatti, José Carlos Tavares Carvalho

Article Affiliation:

Hady Keita

Abstract:

The objectives of this study were to extract and purify Bixin from the seeds ofand to evaluate its hypoglycemic activity, as well as, to conduct anstudy of selectivity on peroxisome proliferator-activated receptors via molecular docking and molecular dynamics simulations. Oral administration of Bixin (10 mg/kg) significantly reduced their glucose level that was alloxan-induced diabetic rats. Bixin showedselectivity on peroxisome proliferator-activated receptors (PPARs), particularly by the peroxisome proliferator-activated receptor gamma (PPARγ), which supports the hypoglycemic activity of Bixin. From the results obtained, it can be inferred that Bixin presents hypoglycemic characteristics, which was confirmed by the results obtained from theandtests. Bixin may act by other pathways to control blood glucose and thus it is possible that it presents a different toxicity profile than troglitazone, rosiglitazone and pioglitazone. However, more studies on the activity and toxicity of Bixin are needed to evaluate for further clinical use. Communicated by Ramaswamy H. Sarma.

Study Type : Animal Study
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