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Abstract Title:

Anti-seizure activity of the aqueous leaf extract of Solanum nigrum linn (solanaceae) in experimental animals.

Abstract Source:

Afr Health Sci. 2008 Jun;8(2):74-9. PMID: 19357754

Abstract Author(s):

Noel N Wannang, Joseph A Anuka, Helen O Kwanashie, Steven S Gyang, Asa Auta

Abstract:

BACKGROUND: Solanum nigrum is claimed in traditional medical practice, to be useful in the treatment of epilepsy in some parts of Nigeria. OBJECTIVES: To study the anti-convulsant property of the aqueous extract of the leaves of S. nigrum in chicks, mice and rats. METHOD: Aqueous extracts were administered intraperitoneally, at a pre-treatment time of 30 minutes, at graded doses and animals were challenged with different types of proconvulsants. RESULTS: The aqueous leaf extract produced a significantly (P<0.05) dose dependent protection against electrically-induced seizure in chicks and rats, pentylenetetrazole-induced seizure in mice and rats and picrotoxin-induced seizure in mice and rats. The anti-seizure property of the extract was potentiated by amphetamine. CONCLUSION: The result obtained in this study suggests that the leaves of this plant may possess anti-convulsant property in chicks, mice and rats.

Study Type : Animal Study

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Sayer Ji
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