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Abstract Title:

Effects of LED -Based Photodynamic Therapy using Red and Blue Lights, with Natural Hydrophobic Photosensitizers on Human Glioma Cell Line.

Abstract Source:

Photodiagnosis Photodyn Ther. 2017 Nov 7. Epub 2017 Nov 7. PMID: 29126958

Abstract Author(s):

Zahra Jamali, Sedigheh Marjaneh Hejazi, Seyed Mohsen Ebrahimi, Hemen Moradi-Sardareh, Maliheh Paknejad

Article Affiliation:

Zahra Jamali

Abstract:

Photodynamic therapy (PDT) has received high attention in cancer treatment due to its minimal side effects, specific cancer-targeting, non-invasion and low cost. It utilizes a specific group of anti-cancer drugs called photosensitizers (PS), which can be only activated under a certain wavelength light illumination and kills cancer cells. To screen the potential of PS and setup of PDT treatment protocol, it is essential to assess the PDT efficacy in vitro. In this study, a light-emitting diode- (LED-) based illumination system at two wavelengths (red&blue) with homogeneous and stable irradiation, and constant temperature conditions in 96-well plates was provided. The photodynamic effect of curcumin (CUR) and methyl ester of 5-aminolevulinic acid (MAL) using LED light on human glioma cell line was investigated. The obtained results indicate that this homemade LED-based illumination system is a favorable light source for in vitro PDT in 96-well plates. The PDT using CUR and MAL was efficient at final concentrations of 25μM and 2mM, and light doses of 60J/cm2 and 40J/cm2 respectively. The blue PDT efficiency was dependent on the light and PS doses. MAL-PDT and CUR-PDT using blue LED significantly decreased cell viability in the treatment groups compared with control groups. Furthermore, MAL-PDT using blue LEDs wasmore effective in comparison with conventional red LEDs on the human glioma cell line.

Study Type : Human In Vitro
Additional Links
Pharmacological Actions : Photosensitizing Agents : CK(1) : AC(1)

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