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Abstract Title:

Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction.

Abstract Source:

Mol Nutr Food Res. 2017 Oct 12. Epub 2017 Oct 12. PMID: 29024402

Abstract Author(s):

Divya Bharat, Rafaela Ramos Mororo Cavalcanti, Chrissa Petersen, Nathan Begaye, Brett Ronald Cutler, Marcella Melo Assis Costa, Renata Kelly Luna Gomes Ramos, Marina Ramos Ferreira, Youyou Li, Leena P Bharath, Emma Toolson, Paul Sebahar, Ryan E Looper, Thunder Jalili, Namakkal S Rajasekaran, Zhenquan Jia, J David Symons, Anandh Babu Pon Velayutham

Article Affiliation:

Divya Bharat

Abstract:

SCOPE: Lipotoxicity-induced endothelial dysfunction is an important vascular complication associated with diabetes. Clinical studies support the vascular benefits of blueberry anthocyanins, but the underlying mechanism is unclear. We tested the hypothesis that metabolites of blueberry anthocyanins attenuate lipotoxicity-induced endothelial dysfunction.

METHODS AND RESULTS: Human aortic endothelial cells (HAECs) were treated for 6 h with either: (i) the parent anthocyanins (malvidin-3-glucoside and cyanidin-3-glucoside); or (ii) the blueberry metabolites (hydroxyhippuric acid, hippuric acid, benzoic acid-4-sulfate, isovanillic acid-3-sulfate, and vanillic acid-4-sulfate), at concentrations known to circulate in humans following blueberry consumption. For the last 5 h HAECs were treated with palmitate or vehicle. HAECs treated with palmitate displayed elevated reactive oxygen species generation, increased mRNA expression of Nox4, chemokines, adhesion molecules, and IκBα, exaggerated monocyte binding, and suppressed nitric oxide production. Of note, the damaging effects of palmitate were ameliorated in HAECs treated with blueberry metabolites but not parent anthocyanins. Further, important translational relevance of these results was provided by our observation that palmitate-induced endothelial dysfunction was lessened in arterial segments that incubated concurrently with blueberry metabolites.

CONCLUSION: Our findings indicate that the vascular benefits of blueberry anthocyanins are mediated by their metabolites. Blueberries might complement existing therapies to improve vascular complications. This article is protected by copyright. All rights reserved.

Study Type : Human In Vitro

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