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Abstract Title:

Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells.

Abstract Source:

Environ Toxicol Pharmacol. 2014 Jul ;38(1):58-70. Epub 2014 May 14. PMID: 24908637

Abstract Author(s):

Dinesh Thummuri, Manish Kumar Jeengar, Shweta Shrivastava, Aparna Areti, Veera Ganesh Yerra, Samyuktha Yamjala, Prashanth Komirishetty, V G M Naidu, Ashutosh Kumar, Ramakrishna Sistla

Article Affiliation:

Dinesh Thummuri

Abstract:

The present study was aimed to evaluvate the apoptogenic potential of ethanolic extract of leaves from Boswellia ovalifoliolata (BL EthOH) and to unravel the molecular mechanisms implicated in apoptosis of Triple Negative Breast Cancer (TNBC) cells. BL EthOH was cytotoxic against TNBC cells like MDA-MB-231 and MDA-MB-453 with IC₅₀ concentrations 67.48 ± 5.45 and 70.03 ± 4.76 μg/ml, respectively. Apoptotic studies showed that BL EthOH was able to induce apoptosis and western blot studies demonstrated that BL EthOH significantly decreased the Phospho-NF-κB (ser536), PCNA, anti-apoptotic protein Bcl-2 expression and increased the expression of pro-apoptotic protein Bax, in MDA-MB-231 and MDA-MB-453 cell lines when compared with untreated cells. Besides, BL EthOH has synergistic chemosensitizing effects on TNBC cells and increased the cytotoxicity of doxorubicin and cisplatin.

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