n/a
Article Publish Status: FREE
Abstract Title:

Effect of Boswellia Serrata Extract on Acute Inflammatory Parameters and Tumor Necrosis Factor-α in Complete Freund's Adjuvant-Induced Animal Model of Rheumatoid Arthritis.

Abstract Source:

Int J Appl Basic Med Res. 2019 Apr-Jun;9(2):100-106. PMID: 31041173

Abstract Author(s):

Rajendra Kumar, Sarvesh Singh, Anil Kumar Saksena, Rishi Pal, Riddhi Jaiswal, Rahul Kumar

Article Affiliation:

Rajendra Kumar

Abstract:

Context: The worldwide prevalence of rheumatoid arthritis (RA) is about 1%, whereas in India, it is approximately 0.75%. The current therapy for RA includes nonsteroidal anti-inflammatory drugs corticosteroids, disease-modifying anti-rheumatic drugs and some recently developed biologic agents, but all of these are associated with adverse effects. Some herbal drugs, such as Boswellia serrata, have been reported to possess anti-inflammatory activity.

Aims: The aim of this study is to evaluate the anti-arthritic activity of Boswellia serrata extract (BSE) in complete Freund's adjuvant (CFA)-induced arthritis in rats.

Materials and Methods: Thirty-six Wistar rats were divided into six equal groups. RA was induced by intradermal injection of 0.1 ml CFA in hind paw. Body weight, ankle diameter, paw volume, arthritic index, tumor necrosis factor-α (TNF-α), and histopathological examination were assessed. The experimental data were statistically assessed by one-way analysis of variance (ANOVA).

Statistical Analysis Used: The recorded data were analyzed using paired-test and ANOVA test using SPSS. The data were analyzed and represented as mean difference. Value of<0.05 was considered statistically significant.

Results: BSE at dose 180 mg/kg showed statistically significant improvement in body weight and decrease in ankle diameter and arthritic index (<0.05); however, there was insignificant change in paw volume (= 0.056). This improvement was comparable with Indomethacin. The level of TNF-α did not show any statistically significant change (= 0.076). Histopathological results also exhibited a reduction in inflammatory parameters.

Conclusions: BSE might have usefulness as an adjunct to conventional therapy of RA.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.