Bisphenol A Activates an Innate Viral Immune Response Pathway.
J Proteome Res. 2019 Dec 9. Epub 2019 Dec 9. PMID: 31816243
Mark L Sowers
Bisphenol A (BPA) is a ubiquitous component in the manufacturing of plastic. It is commonly found in food and beverage containers. Because of its broad exposure and evidence that it may act as an estrogen-like molecule, many have studied its potential effects. Epidemiological studies have found an association between in utero BPA exposure and onset of childhood asthma. Our previous work suggested BPA treated mice induced asthma-like symptoms. Strikingly, these effects were observed in the progeny of exposed dams out to the third generation. To better understand mechanisms and consequences of BPA exposure, we use a proteomics approach. Using both CD4+ T cells from an in vivo model of BPA exposure and an in vitro epithelial cell model, we identified activation of both innate and adaptive immune signaling in BPA. Furthermore our proteomic results from our multigenerational mouse model study implicates aberrant immune activation across several generations. We propose the following, BPA can active an innate viral immune response by upregulating ZDHHC1 and its binding partner, stimulator of interferon-gamma (STING). It also has additional histone epigenetic perturbations suggesting a role for epigenetic inheritance of these immune perturbations.