n/a
Abstract Title:

BPA disrupts the cardioprotection by 17β-oestradiol against ischemia/reperfusion injury in isolated guinea pig hearts.

Abstract Source:

Steroids. 2019 Mar 20. Epub 2019 Mar 20. PMID: 30904504

Abstract Author(s):

Nan Mao, Qinghua Gao, Tong Zhu, Liying Hao

Article Affiliation:

Nan Mao

Abstract:

Bisphenol A (BPA) is an environmental oestrogen or xenoestrogen (XEs). XEs represent a health risk due to their potential for endocrine disruption and ability to mimic estrogenic activity. The effects of BPA on isolated hearts under normal and ischemia/reperfusion (I/R) conditions were investigated for the first time, with a focus on the effects of BPA and 17β-oestradiol (E) co-administration on I/R injury. Our results indicated that BPA at 10M and 10M did not significantly affect Heart rate (HR), coronary flow (CF), lactate dehydrogenase (LDH) or creatine kinase (CK) release in normal or I/R isolated hearts within the 90 minutes. However, Eexerted a protective effect against I/R injury, whereas, BPA inhibited the cardio-protective effects of Eon HR, CF, and LDH and CK release. Furthermore, BPA in combination with Eaggravated I/R injury by increasing infarct size and causing a more severe ultrastructural disruption as compared to treatment with Ealone. Based on our results, we conclude that BPA inhibits the cardio-protective effects of Eon I/R-injured hearts, despite not significantly affecting normal or I/R isolated hearts.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.