Abstract Title:

Bisphenol A-induced epithelial to mesenchymal transition is mediated by cyclooxygenase-2 up-regulation in human endometrial carcinoma cells.

Abstract Source:

Reprod Toxicol. 2015 Nov 4 ;58:229-233. Epub 2015 Nov 4. PMID: 26546977

Abstract Author(s):

Kai-Hung Wang, An-Pei Kao, Chia-Cheng Chang, Ta-Chin Lin, Tsung-Cheng Kuo

Article Affiliation:

Kai-Hung Wang


Many studies have highlighted the correlation between the increase of bisphenol A (BPA) level in the environment and the incidence of tumor in humans. In human carcinogenesis, the overexpression of cyclooxygenase-2 (COX-2) and epithelial-mesenchymal transition (EMT) are closely related with tumor development. In this study, human endometrial carcinoma cells line (RL95-2) was used to investigate whether BPA can induce EMT and COX-2 expression. The results show that BPA increased growth rate and colony-forming efficiency in a dose-dependent manner, induced EMT and COX-2 gene expression and promoted the migration and invasion ability of RL95-2 cells. Furthermore, our study showed that the expression of COX-2 was essential for BPA-induced cell migration and invasion. The results of this study provide new insights into the mechanism of endometrial cancer cell growth and invasion and potential therapeutic strategy.

Study Type : Human In Vitro

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