Abstract Title:

Bisphenol-A promotes antiproliferative effects during neonatal prostate development in male and female gerbils.

Abstract Source:

Reprod Toxicol. 2015 Oct 31. Epub 2015 Oct 31. PMID: 26529182

Abstract Author(s):

Rodrigo Fernandes de Lima, Daniel Andrés Osório Rodriguez, Mônica Souza Campos, Manoel Francisco Biancardi, Iana Figueiredo Ferreira Roriz Dos Santos, Wendyson Duarte de Oliveira, Gláucia Maria Cavasin, Mara Rubia Marques, Sebastião Roberto Taboga, Fernanda Cristina Alcantara Dos Santos

Article Affiliation:

Rodrigo Fernandes de Lima


The aim of this study was to evaluate the development of male and female neonatal gerbil prostate under normal conditions and exposed to bisphenol-A (BPA). Normal postnatal development of the female gerbil prostate occurs earlier than and is morphologically distinct from that occurring in males. In BPA-exposed PND8 gerbils, we have not observed evidence of alterations in the ductal branching in either gender. However, the exposure to BPA alters the immunolabeling pattern of AR, ERα, and PCNA. In males, the exposure to high dosages of BPA resulted in a decrease in the proliferative status of the developing ventral prostate. In females, both high and low dosages were sufficient to decrease the proliferation of paraurethral buds in the branching process by more than 50%. Therefore, the obtained data indicate that BPA promotes antiproliferative effects during the neonatal development of the gerbil prostate, with more sensitivity to this endocrine disruptor in females.

Study Type : Animal Study
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