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Article Publish Status: FREE
Abstract Title:

Garlic (L.): A Brief Review of Its Antigenotoxic Effects.

Abstract Source:

Foods. 2019 Aug 13 ;8(8). Epub 2019 Aug 13. PMID: 31412555

Abstract Author(s):

José Antonio Morales-González, Eduardo Madrigal-Bujaidar, Manuel Sánchez-Gutiérrez, Jeannett A Izquierdo-Vega, María Del Carmen Valadez-Vega, Isela Álvarez-González, Ángel Morales-González, Eduardo Madrigal-Santillán

Article Affiliation:

José Antonio Morales-González

Abstract:

Traditional Medicine/Complementary and Alternative Medicine is a practice that incorporates medicine based on plants, animals, and minerals for diagnosing, treating, and preventing certain diseases, including chronic degenerative diseases such as obesity, diabetes, hypertension, atherosclerosis, and cancer. Different factors generate its continued acceptance, highlighting its diversity, easy access, low cost, and the presence of relatively few adverse effects and, importantly, a high possibility of discovering antigenotoxic agents. In this regard, it is known that the use of different antigenotoxic agents is an efficient alternative to preventing human cancer and that, in general, these can act by means of a combination of various mechanisms of action and against one or various mutagens and/or carcinogens. Therefore, it is relevant to confirm its usefulness, efficacy, and its spectrum of action through different assays. With this in mind, the present manuscript has as its objective the compilation of different investigations carried out with garlic that have demonstrated its genoprotective capacity, and that have been evaluated by means of five of the most outstanding tests (Ames test, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay). Thus, we intend to provide information and bibliographic support to investigators in order for them to broaden their studies on the antigenotoxic spectrum of action of this perennial plant.

Study Type : Review
Additional Links
Pharmacological Actions : Genoprotective : CK(413) : AC(148)

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