Article Publish Status: FREE
Abstract Title:

Brown Seaweedas an Intervention for Diet-Induced Obesity in Male Wistar Rats.

Abstract Source:

Nutrients. 2021 May 21 ;13(6). Epub 2021 May 21. PMID: 34064139

Abstract Author(s):

Ryan du Preez, Marie Magnusson, Marwan E Majzoub, Torsten Thomas, Christina Praeger, Christopher R K Glasson, Sunil K Panchal, Lindsay Brown

Article Affiliation:

Ryan du Preez


The therapeutic potential ofgrown in Australian tropical waters was tested in a rat model of metabolic syndrome. Forty-eight male Wistar rats were divided into four groups of 12 rats and each group was fed a different diet for 16 weeks: corn starch diet (C); high-carbohydrate, high-fat diet (H) containing fructose, sucrose, saturated andfats; and C or H diets with 5%mixed into the food from weeks 9 to 16 (CS and HS). Obesity, hypertension, dyslipidaemia, impaired glucose tolerance, fatty liver and left ventricular fibrosis developed in H rats. In HS rats,decreased body weight (H, 547± 14; HS, 490 ± 16 g), fat mass (H, 248 ± 27; HS, 193 ± 19 g), abdominal fat deposition and liver fat vacuole size but did not reverse cardiovascular and liver effects. H rats showed marked changes in gut microbiota compared to C rats, whilesupplementation increased gut microbiota belonging to the family. This selective increase in gut microbiota likely complements the prebiotic actions of the alginates. Thus,may be a useful dietary additive to decrease abdominal and liver fat deposition.

Study Type : Animal Study

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