Buckwheat grain extract has anti-allergic properties. - GreenMedInfo Summary
Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract.
Int Immunopharmacol. 2003 Jan;3(1):129-36. PMID: 12538043
Oriental Hospital, Oriental Medical College of Daejeon University, 22-5 Daeheung-dong, Daejeon 301-724, South Korea.
The anti-allergic action of buckwheat grain extract (BGE) was investigated using rodent experimental models. The oral, intraperitoneal and intradermal administration of BGE significantly inhibited the compound 48/80-induced vascular permeability documented by Evans blue extravasation. In addition, BGE showed potent inhibitory effect on passive cutaneous anaphylaxis (PCA) activated by anti-dinitrophenyl (DNP) IgE when orally administered. In an in vitro study, BGE revealed to possess inhibitory potential on the compound 48/80-induced histamine release from rat peritoneal mast cells (RPMC). Moreover, BGE inhibited the IL-4 and TNF-alpha mRNA induction by PMA and A23187 in human leukemia mast cells, HMC-1. Taken together, these results suggest that anti-allergic action of BGE may be due to the inhibition of histamine release and cytokine gene expression in the mast cells.