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Abstract Title:

Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract.

Abstract Source:

Int Immunopharmacol. 2003 Jan;3(1):129-36. PMID: 12538043

Abstract Author(s):

Chang Deok Kim, Won-Kyung Lee, Kyong-Ok No, Sang-Ki Park, Min-Ho Lee, Seok Rhin Lim, Seok-Seon Roh

Article Affiliation:

Oriental Hospital, Oriental Medical College of Daejeon University, 22-5 Daeheung-dong, Daejeon 301-724, South Korea.

Abstract:

The anti-allergic action of buckwheat grain extract (BGE) was investigated using rodent experimental models. The oral, intraperitoneal and intradermal administration of BGE significantly inhibited the compound 48/80-induced vascular permeability documented by Evans blue extravasation. In addition, BGE showed potent inhibitory effect on passive cutaneous anaphylaxis (PCA) activated by anti-dinitrophenyl (DNP) IgE when orally administered. In an in vitro study, BGE revealed to possess inhibitory potential on the compound 48/80-induced histamine release from rat peritoneal mast cells (RPMC). Moreover, BGE inhibited the IL-4 and TNF-alpha mRNA induction by PMA and A23187 in human leukemia mast cells, HMC-1. Taken together, these results suggest that anti-allergic action of BGE may be due to the inhibition of histamine release and cytokine gene expression in the mast cells.

Study Type : Animal Study

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Sayer Ji
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