Abstract Title:

Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells.

Abstract Source:

Planta Med. 2006 Feb;72(3):276-8. PMID: 16534737

Abstract Author(s):

T Matsumoto, K Hosono-Nishiyama, H Yamada

Abstract:

In the course of screening for pharmacologically active substances from extracts of crude drugs used traditionally in Sino-Japanese herbal medicines, it was found that the 70 % ethanol extract from the fruits of Arctium lappa L. (Compositae) showed potent antiproliferative activity against B cell hybridoma cell, MH60. By bioassay-guided purification, a new lignan, (+)-7,8-didehydroarctigenin, together with the known lignans (-)-arctigenin and (-)-matairesinol were isolated as the active ingredients from an aqueous ethanolic extract of the fruits of A. lappa. Of these active compounds, (-)-arctigenin showed the most potent antiproliferative activity against MH60 cells (IC (50) : 1.0 microM), and the activity was suggested to be due to apoptosis.

Study Type : In Vitro Study
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