Abstract Title:

Reduced aggregation capacity of washed platelets and dysfibrinogenaemia in rats given butylated hydroxytoluene.

Abstract Source:

Food Chem Toxicol. 1985 Oct;23(10):937-9. PMID: 3934053

Abstract Author(s):

O Takahashi


Calcium-dependent aggregation of washed platelets and the fibrin monomer polymerization (FMP) ratio were determined in rats fed 1.20% butylated hydroxytoluene (BHT) for 7 days. Thrombin-induced aggregation was significantly reduced in rats given BHT, but calcium ionophore A23187-induced aggregation was not. The FMP ratio was significantly increased by BHT administration. These results provide additional evidence of defective platelet function and coagulation-factor abnormality (dysfibrinogenaemia) in rats fed BHT.

Study Type : Animal Study
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