C. aronia exhibits therapeutic and protective effects on NAFLD in an animal model. - GreenMedInfo Summary

Abstract Title:

Protective and therapeutic effects of Crataegus aronia in non-alcoholic fatty liver disease.

Abstract Source:

Arch Physiol Biochem. 2016 Jul 16:1-8. Epub 2016 Jul 16. PMID: 27424611

Abstract Author(s):

Suliman Al Humayed

Article Affiliation:

Suliman Al Humayed

Abstract:

AIM: We evaluated the potential preventive and therapeutic effects of Crataegus aronia (C. aronia) in NAFLD induced by high-fat diet (HFD) in rat models.

METHODS: Protective effect of Crataegus aronia or simvastatin was investigated in Wistar rats fed either low-fat diet (LFD) or HFD.

RESULTS: Liver histopathological examinations confirmed the development of NAFLD in rats fed HFD. In both protective and therapeutic treatments, C. aronia significantly reduced liver index (3.85 ± 0.21% in HFD plus aronia group versus 6.22 ± 0.58% in HFD model group), increased the HDL-cholesterol and reduced the LDL-cholesterol in blood. The hawthorn plant also significantly ameliorated oxidative stress biomarker (p < 0.002) and liver enzymes (p < 0.0001) that indicate liver damage.

CONCLUSION: C. aronia exhibits therapeutic and protective effects on NAFLD in an animal model possibly by its lipid lowering and antioxidant effects; thus, may offer therapeutic potential in humans.

Article Published Date : Jul 15, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn : CK(228) : AC(110)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3124) : AC(882)
Pharmacological Actions : Antioxidants : CK(21528) : AC(13231), Hepatoprotective : CK(5098) : AC(3517), Hypolipidemic : CK(5358) : AC(1880)
Additional Keywords : Risk Reduction : CK(17631) : AC(1963)

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Key Research Topics

Substance

Hawthorn

Pharmacological Actions

Antioxidants
Hepatoprotective
Hypolipidemic

Disease

Nonalcoholic fatty liver disease (NAFLD)

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