Article Publish Status: FREE
Abstract Title:

C-phycocyanin protects against low fertility by inhibiting reactive oxygen species in aging mice.

Abstract Source:

Oncotarget. 2016 Mar 17. Epub 2016 Mar 17. PMID: 27008700

Abstract Author(s):

Yan-Jiao Li, Zhe Han, Lei Ge, Cheng-Jie Zhou, Yue-Fang Zhao, Dong-Hui Wang, Jing Ren, Xin-Xin Niu, Cheng-Guang Liang

Article Affiliation:

Yan-Jiao Li

Abstract:

Women over 35 have higher rates of infertility, largely due to deterioration of oocyte quality characterized by fragmentation, abnormal meiotic spindle-chromosome complexes, and oxidative stress. C-phycocyanin (PC) is a biliprotein enriched in Spirulina platensis that is known to possess antioxidant, anti-inflammatory, and radical-scavenging properties. D-galactose-induced aging acceleration in mice has been extensively used to study aging mechanisms and for pharmaceutical screening. In this study, adult female B6D2F/1 mice injected with D-galactose were used as a model to test the age-reversing effects of PC on degenerated reproductive ability. Our results show that PC can prevent oocyte fragmentation and aneuploidy by maintaining cytoskeletal integrity. Moreover, PC can reverse the expression of antioxidant genes, increase superoxide dismutase (SOD) activity and decrease methane dicarboxylic aldehyde (MDA) content, and normalize mitochondria distribution. PC exerts its benefit by inhibiting reactive oxygen species (ROS) production, which decreases apoptosis. Finally, we observe a significant increase in litter size after PC administration to D-galactose-induced aging mice. Our study demonstrates for the first time that D-galactose-induced impaired female reproductive capability can be partially rescued by the antioxidant effects of PC.

Study Type : Animal Study

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