Protective role of Juniperus phoenicea and Cupressus sempervirens against CCl(4).
World J Gastrointest Pharmacol Ther. 2010 Dec 6 ;1(6):123-31. PMID: 21577307
Sanaa Ahmed Ali, Maha Zaki Rizk, Magda Mohamed Moustafa, Department of Theraputical Chemistry, National Research Centre, El-Behooth Street, 12622 Dokki, Giza, Egypt.
AIM: To investigate the role of Cupressus sempervirens (C. sempervirens) and Juniperus phoenicea (J. phoenicea) extracts as therapeutic effect against CCl(4) with biochemical, histopathological evaluations.
METHODS: A single intraperitoneal dose of 10% CCl(4) in olive oil (1 mL/kg body weight) was administered to a group of female Wister rats, sacrificed after 24 h (as the injury group). The other groups were given CCl(4) as described above and divided as follows: two groups of ten rats each were orally administered either J. phoenicea extract or C. sempervirens extract three times per week for six weeks and a further group administered CCl(4) was left for six weeks to allow self-recovery. At the end of experiment, the rats from all groups were sacrificed for sampling and for biochemical and histological analysis.
RESULTS: Remarkable disturbances were observed in the levels of all tested parameters. On the other hand, rats injected with the toxic agent and left for one and a half month to self recover showed moderate improvements in the studied parameters while, treatment with both medicinal herbal extracts ameliorated the levels of the disturbed biochemical parameters. The group treated with J. phoenicea extract showed a remarkable improvement in comparison to the CCl(4) treated group. The C. sempervirens group revealing an even more remarkable effect showing histopathological liver&kidney profiles close to those of the control group.
CONCLUSION: C. sempervirens and J. phoenicea leaf extracts show a remarkable effect in enhancing liver and kidney functions and may thus be of therapeutic potential in treatment hepatotoxicity and nephrotoxicity.