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Article Publish Status: FREE
Abstract Title:

Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney.

Abstract Source:

Am J Transl Res. 2015 ;7(5):932-40. Epub 2015 May 15. PMID: 26175854

Abstract Author(s):

Feng Du, Si Li, Tian Wang, Hai-Yan Zhang, Zhi-Hong Zong, Zhen-Xian Du, De-Tian Li, Hua-Qin Wang, Bo Liu, Jia-Ning Miao, Xiao-Hui Bian

Article Affiliation:

Feng Du

Abstract:

BAG3 regulates a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, and epithelial-mesenchymal transition (EMT). However, the role of BAG3 in renal tubular EMT and renal interstitial fibrosis remains elusive. This study aimed to examine the dynamic expression of BAG3 during renal fibrosis, and to investigate the efficacy of Cordyceps sinensis (C. sinensis) on renal fibrosis. A rat model of unilateral ureteral obstruction (UUO) was established, and the expression of BAG3 andα-SMA, and the efficacy of C. sinensis on renal fibrosis induced by UUO were examined. The results showed that UUO led to collagen accumulation, which was significantly suppressed by C. sinensis. UUO increased the expression of BAG3 and α-SMA, a mesenchymal marker, while UUO induced BAG3 and α-SMA expression was significantly inhibited by C. sinensis. In addition, immunohistochemical staining demonstrated that BAG3 immunoreactivity was restricted to tubular epithelium. In conclusion, BAG3 is a potential target for the prevention and/or treatment of renal fibrosis, and C. Sinensis is a promising agent for renal fibrosis.

Study Type : Animal Study

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