Abstract Title:

Calf thymus extract attenuates severity of experimental encephalomyelitis in Lewis rats.

Abstract Source:

Folia Neuropathol. 2010;48(4):246-57. PMID: 21225507

Abstract Author(s):

Michał Zimecki, Jolanta Artym, Maciej Kocięba, Jan Kuryszko, Katarzyna Kaleta-Kuratewicz, Krzysztof Marycz

Article Affiliation:

Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, Poland. zimecki@iitd.pan.wroc.pl


The aim of this study was to evaluate the efficacy of treatment of Lewis rats with calf thymus extract (TFX®) and its six-peptide fraction on the course of experimental allergic encephalomyelitis (EAE). Interferon- ß served as a reference drug. We found that intramuscular administration of the thymus extract fraction significantly reduced clinical, immunological, histological, and ultrastructural alterations inherent in the disease. We suggest that TFX® or TFX®-derived fractions have potential as therapeutics in treatment of neurodegenerative diseases such as multiple sclerosis.

Study Type : Animal Study

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