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Article Publish Status: FREE
Abstract Title:

Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium.

Abstract Source:

Int J Environ Res Public Health. 2019 Nov 12 ;16(22). Epub 2019 Nov 12. PMID: 31718076

Abstract Author(s):

Jacopo Junio Valerio Branca, Gabriele Morucci, Matteo Becatti, Donatello Carrino, Carla Ghelardini, Massimo Gulisano, Lorenzo Di Cesare Mannelli, Alessandra Pacini

Article Affiliation:

Jacopo Junio Valerio Branca

Abstract:

The protective effect of cannabidiol (CBD), the non-psychoactive component of, against neuronal toxicity induced by cadmium chloride (CdCl10μM) was investigated in a retinoic acid (RA)-differentiated SH-SY5Y neuroblastoma cell line. CBD (1 μM) was applied 24 h before and removed during cadmium (Cd) treatment. In differentiated neuronal cells, CBD significantly reduced the Cd-dependent decrease of cell viability, and the rapid reactiveoxygen species (ROS) increase. CBD significantly prevented the endoplasmic reticulum (ER) stress (GRP78 increase) and the subcellular distribution of the cytochrome C, as well as the overexpression of the pro-apoptotic protein BAX. Immunocytochemical analysis as well as quantitative protein evaluation by western blotting revealed that CBD partially counteracted the depletion of the growth associated protein 43 (GAP43) and of the neuronal specific class III β-tubulin (β3 tubulin) induced by Cd treatment. These data showed that Cd-induced neuronal injury was ameliorated by CBD treatment and it was concluded that CBD may represent a potential option to protect neuronal cells from the detrimental effects of Cd toxicity.

Study Type : In Vitro Study

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