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Abstract Title:

Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage in newborn piglets.

Abstract Source:

Pediatr Res. 2017 Apr 7. Epub 2017 Apr 7. PMID: 28388598

Abstract Author(s):

Luis Arruza, Maria Ruth Pazos, Nagat Mohammed, Natalia Escribano, Hector Lafuente, Martín Santos, Francisco J Alvarez-Díaz, William Hind, Jose Martínez-Orgado

Article Affiliation:

Luis Arruza

Abstract:

BACKGROUND: Brain hypoxic-ischemic (HI) damage induces distant inflammatory lung damage in newborn pigs. We aimed to investigate the effects of cannabidiol (CBD) on lung damage in this scenario.

METHODS: Newborn piglets received i.v. vehicle, CBD or CBD+WAY100635 (5-HT1A receptor antagonist) after HI brain damage (carotid flow interruption and FiO2 0.10 for 30 min). Total lung compliance (TLC), oxygenation index (OI) and extravascular lung water content (EVLW) were monitored for six hours. Histological damage, interleukin (IL)-1ß concentration and oxidative stress were assessed in brain and lung tissue. Total protein content was determined in bronchoalveolar lavage fluid (BALF).

RESULTS: CBD prevented HI-induced deleterious effects on TLC and OI and reduced lung histological damage, modulating inflammation (decreased leukocyte infiltration and IL-1 concentration) and reducing protein content in BALF and EVLW. These effects were related to CBD-induced anti-inflammatory changes in the brain. HI did not increase oxidative stress in the lungs. In the lungs, WAY100635 blunted CBD's beneficial effects on histological damage, IL-1 concentration and EVLW.

CONCLUSIONS: CBD reduced brain HI-induced distant lung damage, with 5-HT1A receptor involvement in these effects. Whether CBD's effects on lungs were due to anti-inflammatory effects on the brain or to direct effects on lungs remains to be elucidated.Pediatric Research accepted article preview online, 07 April 2017. doi:10.1038/pr.2017.104.

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