Abstract Title:

Evaluation of the role of the cannabidiol system in an animal model of ischemia/reperfusion kidney injury.

Abstract Source:

Rev Bras Ter Intensiva. 2015 Dec ;27(4):383-389. PMID: 26761477

Abstract Author(s):

Rodrigo Zon Soares, Francieli Vuolo, Dhébora Mozena Dall'Igna, Monique Michels, José Alexandre de Souza Crippa, Jaime Eduardo Cecílio Hallak, Antonio Waldo Zuardi, Felipe Dal-Pizzol

Article Affiliation:

Rodrigo Zon Soares


OBJECTIVE: This work aimed to investigate the effects of the administration of cannabidiol in a kidney ischemia/reperfusion animal model.

METHODS: Kidney injury was induced by 45 minutes of renal ischemia followed by reperfusion. Cannabidiol (5mg/kg) was administered immediately after reperfusion.

RESULTS: Ischemia/reperfusion increased the IL-1 and TNF levels, and these levels were attenuated by cannabidiol treatment. Additionally, cannabidiol was able to decrease lipid and protein oxidative damage, but not the nitrite/nitrate levels. Kidney injury after ischemia/reperfusion seemed to be independent of the cannabidiol receptor 1 and cannabidiol receptor 2 (CB1 and CB2) expression levels, as there was no significant increase in these receptors after reperfusion.

CONCLUSION: The cannabidiol treatment had a protective effect against inflammation and oxidative damage in the kidney ischemia/reperfusion model. These effects seemed to be independent of CB1/CB2 receptor activation.

Study Type : Animal Study

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