Abstract Title:

Putative supramolecular complexes formed by carotenoids and xanthophylls with ascorbic Acid to reverse multidrug resistance in cancer cells.

Abstract Source:

Anticancer Res. 2012 Feb ;32(2):507-17. PMID: 22287739

Abstract Author(s):

József Molnár, Julianna Serly, Rozália Pusztai, Irén Vincze, Péter Molnár, Györgyi Horváth, József Deli, Takashi Maoka, Attila Zalatnai, Harukuni Tokuda, Hoyoku Nishino

Article Affiliation:

Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10., Szeged 6720, Hungary. molnarj@comser.szote.u-szeged.hu.


BACKGROUND: The molecular basis of interaction of selected carotenoids and xanthophylls with ascorbic acid on cancer cells was studied to determine their anticancer effects.

MATERIALS AND METHODS: Drug accumulation was measured in a human ABCB1 gene-transfected mouse lymphoma cell line and in a human lung cancer cell line by flow cytometry; furthermore, their anticancer effects were determined in mice in vivo.

RESULTS: Several carotenoids inhibited the multidrug resistance of cancer cells. Ascorbic acid improved the effect of certain xanthophylls, but the effect of capsanthin was not modified. Capsanthin had weak (12%) but capsorubin (85%) had a remarkable antiproliferative effect on A549 lung cancer cells. Capsorubin reduced immediate-early tumor antigen expression, while capsanthin was not effective. Capsorubin accumulates selectively in the nuclei of cancer cells.

CONCLUSION: The Authors suggest a special complex formation between membrane-bound capsorubin and ascorbic acid, which can be exploited in experimental chemotherapy.

Study Type : In Vitro Study

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