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Article Publish Status: FREE
Abstract Title:

Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer.

Abstract Source:

Oncol Lett. 2018 Mar ;15(3):3991-3997. Epub 2018 Jan 8. PMID: 29456744

Abstract Author(s):

Peiguang Niu, Daohua Shi, Shusheng Zhang, Yanting Zhu, Jintuo Zhou

Article Affiliation:

Peiguang Niu

Abstract:

The mammalian target of rapamycin (mTOR) is well-known as a promising therapeutic target in various cancer cells. mTOR activation decreases the sensitivity of ovarian cancer to cisplatin. Cardamonin inhibits the proliferation of various cancer cells by mTOR suppression. The present study examined whether cardamonin combined with cisplatin is efficacious for the anti-proliferation of ovarian cancer cells. The anti-proliferative effect was determined by MTT and cell cycle assays. Activation of the mTOR signal pathway and the expression of anti-apoptotic proteins were evaluated by western blot analysis. Cardamonin significantly enhanced the effects of cisplatin on cell proliferation and cell cycle progression. The expression of B cell lymphoma-2, X-linked inhibitor of apoptosis protein and Survivin was significantly decreased following combination treatment. Furthermore, the activation of mTOR and its downstream 70 kDa ribosomal protein S6 kinase was inhibited by cardamonin. These results demonstrated that the combinatorial effects of cardamonin and cisplatin on anti-proliferation were enhanced by suppressing the expression of anti-apoptotic proteins and activation of mTOR in ovarian cancer cells.

Study Type : In Vitro Study

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Sayer Ji
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