Abstract Title:

Abnormal carnitine distribution in the muscles of patients with idiopathic inflammatory myopathy.

Abstract Source:

Biol Pharm Bull. 2004 Mar;27(3):333-7. PMID: 8912509

Abstract Author(s):

J Arenas, M R Gonzalez-Crespo, Y Campos, M A Martin, A Cabello, J J Gomez-Reino

Article Affiliation:

Hospital Doce de Octubre, Madrid, Spain.

Abstract:

OBJECTIVE: To analyze the levels of free carnitine and carnitine esters in the muscles of patients with inflammatory myopathies. METHODS: Six men and 7 women with inflammatory myopathy and 25 age-matched healthy controls were studied. Free carnitine and carnitine esters in muscle homogenates were measured by a radiochemical procedure. Muscle histochemical staining and measurement of respiratory chain enzyme activity were also performed. RESULTS: Eleven patients had muscle carnitine insufficiency. Five of them had subsarcolemmal oxidative accumulations, 5 had lipid droplets, and 4 had defects of the respiratory chain enzyme complexes. CONCLUSION: Abnormal distribution of muscle carnitine is present in patients with inflammatory myopathies and could impair muscle function. Coexistent mitochondrial dysfunction may contribute to carnitine insufficiency.

Study Type : Human Study

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