Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2. - GreenMedInfo Summary
Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2.
Oncotarget. 2018 Sep 28 ;9(76):34200-34212. Epub 2018 Feb 6. PMID: 30344937
Carnosol is a phenolic diterpene that is isolated from rosemary, sage, and oregano. It has been reported to possess anti-oxidant, anti-inflammatory, and anti-cancer properties. However, the molecular mechanism of carnosol's activity against gastric cancer has not been investigated. Herein, we report that carnosol is an RSK2 inhibitor that attenuates gastric cancer growth. Carnosol reduced anchorage-dependent and -independent gastric cancer growth by inhibiting the RSKs-CREB signaling pathway. The results ofscreening and cell-based assays indicated that carnosol represses RSK2 activity and its downstream signaling. Carnosol increased the G2/M phase and decreased S phase cell cycle and also induced apoptosis through the activation of caspases 9 and 7 and inhibition of Bcl-xL expression. Notably, oral administration of carnosol suppressed patient-derived gastric tumor growth in anmouse model. Our findings suggest that carnosol is an RSK2 inhibitor that could be useful for treating gastric cancer.