Abstract Title:

The Effects of Resveratrol, Caffeine,β-Carotene, and Epigallocatechin Gallate (EGCG) on Amyloid-Aggregation in Synthetic Brain Membranes.

Abstract Source:

Mol Nutr Food Res. 2020 Nov ;64(22):e2000632. Epub 2020 Oct 19. PMID: 32981185

Abstract Author(s):

Isabella P Gastaldo, Sebastian Himbert, Udbhav Ram, Maikel C Rheinstädter

Article Affiliation:

Isabella P Gastaldo


SCOPE: Alzheimer's disease is a neurodegenerative condition marked by the formation and aggregation of amyloid-β (Aβ) peptides. There exists, to this day, no cure or effective prevention for the disease; however, there is evidence that a healthy diet and certain food products can slow down first occurrence and progression. To investigate if food ingredients can interact with peptide aggregates, synthetic membranes that contained aggregates consisting of cross-β sheets of the membrane active fragment Aare prepared.

METHODS AND RESULTS: The impact of resveratrol, found in grapes, caffeine, the main active ingredient in coffee,β-carotene, found in orange fruits and vegetables, and epigallocatechin gallate (EGCG), a component of green tea, on the size and volume fraction of Aβ aggregates is studied using optical and fluorescence microscopy, X-ray diffraction, UV-vis spectroscopy, and molecular dynamics simulations. All compounds are membrane active and spontaneously partitioned in the synthetic brain membranes. While resveratrol and caffeine lead to membrane thickening and reduced membrane fluidity, β-carotene and EGCG preserve or increase fluidity.

CONCLUSION: Resveratrol and caffeine do not reduce the volume fraction of peptide aggregates whileβ-carotene significantly reduces plaque size. Interestingly, EGCG dissolves peptide aggregates and significantly decreases the corresponding cross-β and β-sheet signals.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.