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Article Publish Status: FREE
Abstract Title:

β-carotene provides neuro protection after experimental traumatic brain injury via the Nrf2-ARE pathway.

Abstract Source:

J Integr Neurosci. 2019 Jun 30 ;18(2):153-161. PMID: 31321956

Abstract Author(s):

Peiqing Chen, Lin Li, Yongfeng Gao, Zhuqing Xie, Yin Zhang, Zhoujia Pan, Yingxin Tu, Hu Wang, Qiuqin Han, Xiamin Hu, Xiaoming Xin

Article Affiliation:

Peiqing Chen

Abstract:

We investigate whetherβ-carotene, a known natural antioxidant, can reduce oxidative stress induced by traumatic brain injury. In addition, we investigated the underlying mechanism of traumatic brain injury focusing on the NF-E2-related factor (Nrf2) pathway. A controlled cortical impact model was used to mimic traumaticbrain injury. Using this model, we evaluated brain edema, lesion volume, neurologic deficits, reactive oxygen species, and the expression of Nrf2-related protein markers. The results of our study demonstrated that cognitive performance and neural functions were improved with β-carotene administration. In addition, β-carotene reduced brain edema and reactive oxygen species levels after traumatic brain injury. Nrf2 nuclear accumulation was increased and was accompanied by decreased Keap1 expression. The expression of quinone oxidoreductase 1, a target gene of the Nrf2 signaling pathway was increased. However, lesion volume was not significantly reduced after β-carotene treatment. Taken together, our data demonstrated that β-carotene administration was neuroprotective and alleviated oxidative stress by modulating the Nrf2/Keap1- mediated antioxidant pathway in the traumatic brain injury model.

Study Type : In Vitro Study

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