Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2.
Antiviral Res. 1999 Jul;42(3):219-26. PMID: 10443534
Children's Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229-3039, USA.
There is considerable interest in developing topical microbicides; products to be used intravaginally by women for protection against sexually transmitted diseases. Many compounds derived from plants have been shown to have antimicrobial properties. We examined 19 such compounds in vitro by plaque reduction assay to determine their activity against a common sexually transmitted pathogen, herpes simplex virus type 2. Compounds with an ED50