Abstract Title:

Cashew (L.) Nuts Counteract Oxidative Stress and Inflammation in an Acute Experimental Model of Carrageenan-Induced Paw Edema.

Abstract Source:

Antioxidants (Basel). 2020 Jul 24 ;9(8). Epub 2020 Jul 24. PMID: 32722199

Abstract Author(s):

Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Ramona D'Amico, Alessio Filippo Peritore, Enrico Gugliandolo, Tiziana Genovese, Maria Scuto, Rosalia Crupi, Giuseppina Mandalari, Salvatore Cuzzocrea, Rosanna Di Paola, Daniela Impellizzeri

Article Affiliation:

Marika Cordaro


BACKGROUND: L. is a medicinal plant with powerful anti-oxidative and anti-inflammatory properties. Acute inflammatory events cause tissue alterations, decrease of anti-oxidative endogenous enzymes such as superoxide dismutase, catalase and glutathione, neutrophils infiltration, increase in the activities of myeloperoxidase, malondialdehyde, and pro-inflammatory release.

METHODS: Paw edema was induced by subplantar injection of carrageenan into the right hind paw in rats, but 30 min before a group of animals were orally treated with 100 mg/kg of cashew nuts to evaluate the anti-inflammatory and anti-oxidative response.

RESULTS: In the present work, we found that (1) cashew nuts reduced the development of carrageenan-induced paw edema limiting the formation of edema and pain; (2) cashew nuts ameliorated the diminutions of the anti-oxidative enzymes caused by carrageenan injection; (3) cashew nuts decreased myeloperoxidase malondialdehyde activity induced by carrageenan; and (4) cashew nuts acted by blocking pro-inflammatory cytokines response and nitrate/nitrite formation stimulated by carrageenan injection.

CONCLUSIONS: The mechanisms of anti-inflammatory and analgesic effects exerted by cashew nuts were relevant to oxygen free radical scavenging, anti-lipid peroxidation, and inhibition of the formation of inflammatory cytokines.

Study Type : Animal Study

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