Abstract Title:

Power surge: supporting cells"fuel"cancer cell mitochondria.

Abstract Source:

Cell Metab. 2012 Jan 4 ;15(1):4-5. PMID: 22225869

Abstract Author(s):

Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti

Article Affiliation:

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract:

An emerging paradigm in tumor metabolism is that catabolism in host cells"fuels"the anabolic growth of cancer cells via energy transfer. A study in Nature Medicine (Nieman et al., 2011) supports this; they show that triglyceride catabolism in adipocytes drives ovarian cancer metastasis by providing fatty acids as mitochondrial fuels.

Study Type : Review

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