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Article Publish Status: FREE
Abstract Title:

Celastrol Inhibits the Growth of Ovarian Cancer Cellsand.

Abstract Source:

Front Oncol. 2019 ;9:2. Epub 2019 Jan 28. PMID: 30746340

Abstract Author(s):

Li-Na Xu, Na Zhao, Jin-Yan Chen, Piao-Piao Ye, Xing-Wei Nan, Hai-Hong Zhou, Qi-Wei Jiang, Yang Yang, Jia-Rong Huang, Meng-Ling Yuan, Zi-Hao Xing, Meng-Ning Wei, Yao Li, Zhi Shi, Xiao-Jian Yan

Article Affiliation:

Li-Na Xu

Abstract:

Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cellsandis still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Pretreatment with ROS scavenger N-acetyl-cysteine totally blocked the apoptosis induced by celastrol. Additionally, celastrol inhibited the growth of ovarian cancer xenografts in nude mice. Altogether, these findings suggest celastrol is a potential therapeutic agent for treating ovarian cancer.

Study Type : Animal Study, In Vitro Study

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