Abstract Title:

Anti-arthritic activity of cell wall content of Lactobacillus plantarum in freund's adjuvant-induced arthritic rats: involvement of cellular inflammatory mediators and other biomarkers.

Abstract Source:

Inflammopharmacology. 2017 Jul 6. Epub 2017 Jul 6. PMID: 28685302

Abstract Author(s):

Priyanshee Gohil, Vimal Patel, Shrikalp Deshpande, Mehul Chorawala, Gaurang Shah

Article Affiliation:

Priyanshee Gohil


Alteration of microbiota is related with rheumatoid arthritis (RA) and administration of certain probiotics showed an improvement in RA. The present study was designed to find out the anti-arthritic activity of cell wall content of Lactobacillus plantarum in complete Freund's adjuvant (CFA)-induced arthritis in rats. Freund's adjuvant was injected into the left footpad in female rats on day 0 and dexamethasone (1 mg kg(-1), s.c.)&cell wall content of L. plantarum (10(5), 10(7), and 10(9) cfu/animal, s.c.) treatment were given from day 7 to 21. The change in body weight, paw volume and arthritic index, joint stiffness, gait test, mobility test, erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP) level, serum rheumatoid factor (RF), and serum TNF-α was measured onday 21. Cell wall content of L. plantarum treated animals showed improvement in all the parameters as compared to that in CFA-treated animals and exert anti-arthritic activity.

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