n/a
Article Publish Status: FREE
Abstract Title:

Attenuates Mitochondrial Dysfunction and Oxidative Stress in A-Exposed Hippocampal Neurons.

Abstract Source:

Oxid Med Cell Longev. 2017 ;2017:7023091. Epub 2017 Aug 13. PMID: 28883904

Abstract Author(s):

Nora E Gray, Jonathan A Zweig, Donald G Matthews, Maya Caruso, Joseph F Quinn, Amala Soumyanath

Article Affiliation:

Nora E Gray

Abstract:

has been used for centuries to enhance memory. We have previously shown that a water extract of(CAW) protects against the deleterious effects of amyloid-(A) in neuroblastoma cells and attenuates A-induced cognitive deficits in mice. Yet, the neuroprotective mechanism of CAW has yet to be thoroughly explored in neurons from these animals. This study investigates the effects of CAW on neuronal metabolism and oxidative stress in isolated A-expressing neurons. Hippocampal neurons from amyloid precursor protein overexpressing Tg2576 mice and wild-type (WT) littermates were treated with CAW. In both genotypes, CAW increased the expression of antioxidant response genes which attenuated the A-induced elevations in reactive oxygen species (ROS) and lipid peroxidation in Tg2576 neurons. CAW also improved mitochondrial function in both genotypes and increased the expression of electron transport chain enzymes and mitochondrial labeling, suggesting an increase in mitochondrial content. These data show that CAW protects against mitochondrial dysfunction and oxidative stress in A-exposed hippocampal neurons which could contribute to the beneficial effects of the extract observed in vivo. Since CAW also improved mitochondrial function in the absence of A, these results suggest a broader utility for other conditions where neuronal mitochondrial dysfunction occurs.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.