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Article Publish Status: FREE
Abstract Title:

Characterization of synergistic antibacterial effect of silver nanoparticles and ebselen.

Abstract Source:

Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):3338-3349. PMID: 31387398

Abstract Author(s):

Xueqing Chen, Heming Chen, Hongying Zhang, Yanjuan Peng, Fuchang Deng, Jiye Gao, Chunli Chai, Song Tang, Xin Zuo, Jun Lu, Huamao Du

Article Affiliation:

Xueqing Chen

Abstract:

The emerging and spreading of multi-drug resistant (MDR) bacteria have been becoming one of the most severe threats to human health. Enhancing oxidative stress as mimicking immune system was considered as a potential strategy to fight against infection of MDR bacteria. In this study, we investigated the antibacterial efficiency of such a strategy which combines silver nanoparticles (AgNPs) with ebselen. The results showed that AgNPs and ebselen combination had significant synergistic killing effects both on() and(), including model strains of China Veterinary Culture Collection and MDR clinical isolates, which is similar as the combination of silver ion and ebselen. AgNPs exhibited to be a strong inhibitor of bacterial thioredoxin reductase, same as a free silver ion. Ebselen mitigated the cytotoxicity of AgNPs to HeLa cells. However, in a bacteria-cell coexistence condition, the synergistic bactericidal effect was only observed on(<.05), while the temporary synergistic inhibitory effect onwithin 4 hours treatment (<.01). In mice infection model, a combination of AgNPs and ebselen did not increase protection against the challenge of clinicalCQ10 strain. Our data demonstrated that AgNPs and ebselen combination may be a promising strategy to fight against the increasingly MDR bacteria targeting bacterial thiol redox system.

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