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Article Publish Status: FREE
Abstract Title:

Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro.

Abstract Source:

J Enzyme Inhib Med Chem. 2009 Oct ;24(5):1138-40. PMID: 19772486

Abstract Author(s):

Seung Hyun Kim, Mi Kyeong Lee, Ki Yong Lee, Sang Hyun Sung, Jinwoong Kim, Young Choong Kim

Article Affiliation:

Seung Hyun Kim

Abstract:

The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H(2)O(2). Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H(2)O(2)-induced neurotoxicity.

Study Type : In Vitro Study

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