n/a
Abstract Title:

[Chemical Constituents from Leaves of Hibiscus syriacus and Theirα-Glucosidase Inhibitory Activities].

Abstract Source:

Zhong Yao Cai. 2015 May ;38(5):975-9. PMID: 26767290

Abstract Author(s):

Qiang Wei, Xiao-ying Ji, Fei Xu, Qian-rong Li, Hao Yin

Article Affiliation:

Qiang Wei

Abstract:

OBJECTIVE: To study the chemical constituents from Hibiscus syriacus leaves and theirα-glucosidase inhibitory activities.

METHODS: Column chromatography including macroporous resins, silica gel and Sephadex LH-20 were used for the isolation and purification of all compounds. Spectroscopic methods including physical and chemical properties, 1H-NMR and 13C-NMR were used for the identification of structures. Theirα-glucosidase inhibitory activities were detected by a 96-well microplate.

RESULTS: 15 compounds were isolated and identified asβ-sitosterol(1), β-daucostero (2), β-amyrin (3), oleanolic acid (4), stigmast-4-en-3-one (5), friedelin (6), syriacusin A (7), kaempferol (8), isovitexin (9), vitexin (10), apigenin (11), apigenin-7-O-β-D-glucopyranoside (12), luteolin-7-O-β-D-glucopyranoside (13), vitexin-7-O-β-D-glucopyranoside (14) and rutin (15).

CONCLUSION: All the compounds are isolated from the leaves of Hibiscus syriacus for the first time. Taking acarbose as positive control, theα-glucosidase inhibitory activities of 15 compounds were evaluated. Compounds 7 and 9 have shown strong α-glucosidase inhibitory activities with IC50 of 39.03 ± 0.38 and 32.12 ± 0.62 mg/L, inhibition ratio of 94.95% and 97.15%, respectively.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.