Abstract Title:

[Chemical Constituents from Leaves of Hibiscus syriacus and Theirα-Glucosidase Inhibitory Activities].

Abstract Source:

Zhong Yao Cai. 2015 May ;38(5):975-9. PMID: 26767290

Abstract Author(s):

Qiang Wei, Xiao-ying Ji, Fei Xu, Qian-rong Li, Hao Yin

Article Affiliation:

Qiang Wei


OBJECTIVE: To study the chemical constituents from Hibiscus syriacus leaves and theirα-glucosidase inhibitory activities.

METHODS: Column chromatography including macroporous resins, silica gel and Sephadex LH-20 were used for the isolation and purification of all compounds. Spectroscopic methods including physical and chemical properties, 1H-NMR and 13C-NMR were used for the identification of structures. Theirα-glucosidase inhibitory activities were detected by a 96-well microplate.

RESULTS: 15 compounds were isolated and identified asβ-sitosterol(1), β-daucostero (2), β-amyrin (3), oleanolic acid (4), stigmast-4-en-3-one (5), friedelin (6), syriacusin A (7), kaempferol (8), isovitexin (9), vitexin (10), apigenin (11), apigenin-7-O-β-D-glucopyranoside (12), luteolin-7-O-β-D-glucopyranoside (13), vitexin-7-O-β-D-glucopyranoside (14) and rutin (15).

CONCLUSION: All the compounds are isolated from the leaves of Hibiscus syriacus for the first time. Taking acarbose as positive control, theα-glucosidase inhibitory activities of 15 compounds were evaluated. Compounds 7 and 9 have shown strong α-glucosidase inhibitory activities with IC50 of 39.03 ± 0.38 and 32.12 ± 0.62 mg/L, inhibition ratio of 94.95% and 97.15%, respectively.

Study Type : In Vitro Study

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Sayer Ji
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