Article Publish Status: FREE
Abstract Title:

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets.

Abstract Source:

J Cancer Prev. 2020 Sep 30 ;25(3):136-151. PMID: 33033708

Abstract Author(s):

Rohini Gomathinayagam, Ji Hee Ha, Muralidharan Jayaraman, Yong Sang Song, Ciro Isidoro, Danny N Dhanasekaran

Article Affiliation:

Rohini Gomathinayagam


Thymoquinone (TQ) is a bioactive component derived from the seeds ofthat are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

Study Type : Review

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