Abstract Title:

137Cesium exposure and spirometry measures in Ukrainian children affected by the Chernobyl nuclear incident.

Abstract Source:

Environ Health Perspect. 2010 May;118(5):720-5. Epub 2010 Jan 25. PMID: 20100677

Abstract Author(s):

Erik R Svendsen, Igor E Kolpakov, Yevgenia I Stepanova, Vitaliy Y Vdovenko, Maryna V Naboka, Timothy A Mousseau, Lawrence C Mohr, David G Hoel, Wilfried J J Karmaus

Article Affiliation:

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208 , USA. svendsee@mailbox.sc.edu

Abstract:

BACKGROUND: After the Chernobyl accident in 1986, children of the contaminated Narodichesky region of Ukraine were obliged to participate in a yearly medical screening. They have been exposed to 137cesium (137Cs; half-life = 30 years) in contaminated soils, air, and food.

OBJECTIVE: Using a "natural experiment" approach and a longitudinal prospective cohort study design, we investigated the association of soil 137Cs and spirometry measures for 415 children using 1,888 repeated measurements from 1993 to 1998.

METHODS: Mean baseline village soil 137Cs measurements, which varied from 29.0 to 879 kBq/m2, were used as exposure indicators. A standardized spirometry protocol and prediction equations specific to Ukrainian children were used by the same pulmonologist in all screenings.

RESULTS: Children living in villages with the highest quintile of soil 137Cs were 2.60 times more likely to have forced vital capacity (FVC)<80% of predicted [95% confidence interval (CI), 1.07-6.34] and 5.08 times more likely to have a ratio of forced expiratory volume in 1 sec (FEV1) to FVC%<80% (95% CI, 1.02-25.19). We found statistically significant evidence of both airway obstruction (FEV1/FVC%, peak expiratory flow, and maximum expiratory flow at 25%, 50%, and 75% of FVC) and restriction (FVC) with increasing soil 137Cs.

CONCLUSIONS: These findings are unique and suggest significant airway obstruction and restriction consequences for children chronically exposed to low-dose radioactive contaminants such as those found downwind of the Chernobyl Nuclear Power Plant.

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