Abstract Title:

[Experimental study on effect of qishejingkang recipe on activity of alkaline phosphatases in osteophyte formation of degenerated cervical vertebrae of rabbits].

Abstract Source:

Arch Ophthalmol. 2001 Oct;119(10):1417-36. PMID: 11789285

Abstract Author(s):

Y Wang, Q Shi, P Shen

Article Affiliation:

Institute of Orthopedics and Traumatology, Shanghai University of TCM, Shanghai (200032).


OBJECTIVE: To study the effect of Qishejingkang recipe (QSJKR) on activity of alkaline phosphatase (ALP) in osteophyte formation of degenerated cervical vertebrae. METHODS: A model of degenerated cervical vertebrae in the rabbit was established through resection of the cervical supraspinous and interspinous ligaments from the cervical spine elicited by surgical intervention. The sites of osteophyte was observed with a light microscope. The activity of ALP of the annuls fibrosis and nucleus pulpous, end-plate in each cervical spine was assayed with biochemical method respectively. RESULTS: Osteophyte come from end-plate, the activity of ALP in the degenerated end-plate in QSJKR group declined significantly compared with model group. CONCLUSION: QSJKR could decrease the activity of ALP in end-plate of degenerated cervical vertebrae and it might inhibit the formation of osteophyte.

Study Type : Animal Study

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