Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice. - GreenMedInfo Summary
Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice.
Food Sci Nutr. 2019 Feb ;7(2):579-588. Epub 2019 Jan 28. PMID: 30847137
To evaluate the anti-obesity effects of chlorogenic acid (CGA), the mice were fed a high-fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD-induced gutmicrobiota dysbiosis, including significantly inhibiting the growth ofand raising the growth of. Overall, the amelioration of HFD-induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD-induced obesity.