Abstract Title:

Chlorogenic Acid from Hawthorn Berry (Crataegus pinnatifida Fruit) Prevents Stress Hormone-Induced Depressive Behavior, through Monoamine Oxidase B-Reactive Oxygen Species Signaling in Hippocampal Astrocytes of Mice.

Abstract Source:

Mol Nutr Food Res. 2018 Jun 12:e1800029. Epub 2018 Jun 12. PMID: 29893510

Abstract Author(s):

Dong Wook Lim, Taewon Han, Jonghoon Jung, Yuri Song, Min Young Um, Minseok Yoon, Yun Tai Kim, Seungmok Cho, In-Ho Kim, Daeseok Han, Changho Lee, Jaekwang Lee

Article Affiliation:

Dong Wook Lim


SCOPE: Oxidative stress has been implicated in mental disorders, including depression. Chlorogenic acid (CGA), one of the abundant phenolic compounds in herbs and fruits, has the properties of a natural antioxidant and free-radical scavenger. Therfore, we investigated the antidepressant-like effects and active mechanisms of CGA from the extract of Crataegus pinnatifida (CP) fruit.

METHODS AND RESULTS: Depression-like phenotypes were induced in mice by daily injection of stress hormone for 1-2 weeks. The brains of these animals exhibited reduced brain-derived neurotrophic factor expression and increased astrocytic hypertrophy, which are typical markers of depression in animal models. Stress hormone injection 1) upregulated monoamine oxidase B (MAOB) expression and 2) reduced spine numbers along neuronal dendrites, which indicates synaptic depression. The oral administration of CGA (30 mg kg) or CP (300 mg kg) prevented MAOB activation following reactive oxygen species (ROS) production and had an ameliorative effect on depressive behavioral tests (e.g., tail suspension and forced swim tests). In vitro assays performed on cultured C8-D1A cells revealed that CGA and CP inhibited MAOB activity and ROS production.

CONCLUSION: Our study indicates that CGA and CP extracts prevented depressive behavior and thereby have potential as natural antidepressants.

Study Type : Animal Study

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