Cholinesterase inhibitory alkaloids from the rhizomes of Coptis chinensis. - GreenMedInfo Summary
Cholinesterase inhibitory alkaloids from the rhizomes of Coptis chinensis.
Bioorg Chem. 2018 Feb 23 ;77:625-632. Epub 2018 Feb 23. PMID: 29502023
Thao Quyen Cao
Coptis chinensis has been used as a medicinal herb in traditional oriental medicine. In this study, chemical investigation of a water extract of C. chinensis identified two new quaternary protoberberines (1, 2), a new tricyclic amide (3), together with five known compounds. Their chemical structures were elucidated by analysis with 1D and 2D NMR and high-resolution mass spectroscopy, as well as by comparison with those reported in the literature. Compounds 4, 5, and 7 showed potent inhibition against acetylcholinesterase (AChE) with ICvalues of 1.1, 5.6, and 12.9 μM, respectively. Compounds 2 and 4 showed inhibition of butyrylcholinesterase (BChE) with ICvalues of 11.5 and 27.8 μM, respectively. The kinetic activities were investigated to find out the type of enzyme inhibition involved. The types of AChE inhibition shown by compounds 5 and 7 were noncompetitive; BChE inhibition by compound 2 was also noncompetitive.