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Abstract Title:

Chronic exposure to aluminum and risk of Alzheimer's disease: A meta-analysis.

Abstract Source:

Neurosci Lett. 2016 Jan 1 ;610:200-6. Epub 2015 Nov 27. PMID: 26592479

Abstract Author(s):

Zengjin Wang, Xiaomin Wei, Junlin Yang, Jinning Suo, Jingyi Chen, Xianchen Liu, Xiulan Zhao

Article Affiliation:

Zengjin Wang

Abstract:

A meta-analysis was performed to investigate whether chronic exposure to aluminum (Al) is associated with increased risk of Alzheimer's disease (AD). Eight cohort and case-control studies (with a total of 10567 individuals) that met inclusion criteria for the meta-analysis were selected after a thorough literature review of PubMed, Web of Knowledge, Elsevier ScienceDirect and Springer databases up to June, 2015. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of included studies. Q test and I(2) statistic were used to examine heterogeneity between selected studies. The overall odds ratio (OR) was calculated using a fixed-effect model because no significant heterogeneity between studies was found. No publication bias was observed based on a funnel plot and Egger's test. Results showed that individuals chronically exposed to Al were 71% more likely to develop AD (OR: 1.71, 95% confidence interval (CI), 1.35-2.18). The finding suggests that chronic Al exposure is associated with increased risk of AD.

Study Type : Meta Analysis
Additional Links
Anti Therapeutic Actions : Vaccination: All : CK(6351) : AC(662)
Problem Substances : Aluminum : CK(533) : AC(185)

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