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Abstract Title:

A new anti-HIV flavonoid glucuronide from Chrysanthemum morifolium.

Abstract Source:

Planta Med. 2003 Sep;69(9):859-61. PMID: 14598216

Abstract Author(s):

Ji Sun Lee, Hyoung Ja Kim, Yong Sup Lee

Article Affiliation:

Division of Life Sciences, Korea Institute of Science and Technology, Cheongryang, Seoul 130-650, Korea.

Abstract:

A new flavonoid glucuronide, apigenin 7-O-beta-D-(4'-caffeoyl)glucuronide (1), and the known compound, apigenin 7-O-beta-D-glucurnoide, were isolated from the flowers of Chrysanthemum morifolium, along with five known flavonoids. The structure of 1 was elucidated by the aid of spectroscopic analyses. Among isolated compounds, apigenin 7-O-beta-D-(4"-caffeoyl)glucuronide showed strong HIV-1 integrase inhibitory activity (IC (50) = 7.2 +/- 3.4 microg/ml) and anti-HIV activity in a cell culture assay (EC (50) = 41.86 +/- 1.43 microg/ml) using HIV-I (IIIB) infected MT-4 cells.

Study Type : In Vitro Study

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