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Abstract Title:

Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease.

Abstract Source:

Neurosci Lett. 2019 07 27 ;706:158-163. Epub 2019 May 20. PMID: 31121284

Abstract Author(s):

Lucian Del Fabbro, André Rossito Goes, Cristiano Ricardo Jesse, Marcelo Gomes de Gomes, Leandro Cattelan Souza, Fernando V Lobo Ladd, Aliny A B Lobo Ladd, Ricardo Vinicius Nunes Arantes, Astor Reis Simionato, Mauro Schneider Oliveira, Ana Flavia Furian, Silvana Peterini Boeira

Article Affiliation:

Lucian Del Fabbro

Abstract:

Parkinson's disease (PD) is an age-related neurodegenerative disorder that severely affects quality of life of patients and their families. The flavonoid chrysin (5,7-dihydroxylflavone) is a naturally occurring flavone with several pharmacological activities, including anti-inflammatory and anti-oxidative. We investigated the effects of a 28-day chrysin treatment (10 mg/kg/day, i.g.) on a model of PD induced by 6-OHDA in aged (20-month old) mice. We found a protective effect of chrysin on behavioral and cognitive alterations (rotational behavior, passive avoidance and Barnes maze tests), nitric oxide synthesis (NOx), lipid peroxidation (HNE), glutathione levels (GSH), reactive species levels (RS), neuroinflammation (interleukin-1 beta - IL-1β and tumor necrosis factor alpha - TNF-α), Na, K-ATPase and nicotinamide adenine dinucleotide phosphate oxidase activity (NADPH oxidase) activities. In addition, chrysin protected against changes in striatal dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels. In conclusion, chrysin improved several behavioral, cognitive and neurochemical parameters in a relevant preclinical model of PD in aged mice.

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